The fastest way to soften gray nails is mainly through medicated sealing. You can also soften the treatment by soaking in warm water and applying softeners. 1. sealing: urea, salicylic acid and other drugs can be used to seal, to play the effect of softening gray nail. 2. Apply softening agent: you can use boric acid solution to wet compress the affected nails, wait for 10-15 minutes and then rinse it off, which can also play a role in softening the nails. 3. Soak in warm water: You can soak the nail in warm water and keep it for 15-20 minutes to soften the nail. Softening at the same time need to cooperate with antifungal treatment. It is recommended that patients with gray nails go to the hospital in time, follow the doctor’s instructions for treatment, to avoid delaying the condition.