Glutamine alone cannot treat depression. Glutathione has the effect of regulating autonomic dysfunction, and is mainly used to sedate and help sleep in neurosis, premenstrual tension syndrome, menopausal syndrome and other diseases. It can relieve anxiety-induced nervous exhaustion, but cannot stimulate nerve excitation, so it cannot be used to treat depression. Occasional stomach upset, nausea, vomiting, dry mouth, breast swelling, rash, excessive oil secretion, hair loss, weight gain, etc., which can be alleviated or disappeared after stopping or reducing the dosage. Use with caution in patients with gastric and duodenal ulcers and allergic individuals. Glutathione can only be used as an adjunctive therapy, which is helpful in the treatment of insomnia and other complications caused by depression. The treatment of depression needs to be targeted, systematic and standardized, and the rational use of medication should take into account the patient’s age, gender, physical condition and other factors. 5-hydroxytryptamine reuptake inhibitors, 5-hydroxytryptamine and norepinephrine reuptake inhibitors, norepinephrine and specific 5-hydroxytryptamine receptor antagonists are recommended as the first-line drug treatment for depression. In addition, it is contraindicated in patients who are hypersensitive to the ingredients contained in glutamine. For specific use of Glutathione or other depression medications, follow the drug’s instructions or take the medication as prescribed by your doctor in a regular hospital.