The formation of blood blisters may be related to local friction or viral infection, and the treatment needs to be based on the specific cause of the corresponding treatment. 1. local friction: for the local repeated friction caused by the blood blisters, can go to the hospital by the professional medical personnel to deal with, need to use a sterile syringe to draw out the blisters; and topical antibiotics to prevent infection, such as erythromycin ointment. 2. Viral infections: chickenpox, herpes zoster and other viral infections caused by blood blisters, in the treatment of the first anti-viral drugs (acyclovir, vasiclovir), the larger blood blisters can be used to extract the blisters with a syringe, and secondly, we should pay attention to the good care of the skin, to avoid scratching and scratching stimulation. Due to the individual differences in clinical manifestations, the specific treatment needs to be consulted by a doctor, and the specific medication and treatment should follow the doctor’s instructions.