Thyroid class III nodules, i.e. thyroid grade 3 nodules, can mostly return to normal after active treatment. According to the international TI-RADS grading principle, thyroid nodules are clinically categorized into 6 grades, with each grade representing a different condition. Generally speaking, grade 1-3 thyroid nodules are benign lesions, while grade 4 or above nodules have a higher possibility of malignancy as the classification level goes up. Most grade 3 thyroid nodules are mainly solid, with isoechoic and clear borders on ultrasound. The risk of malignancy is less than 2%, and most patients can be cured with active treatment after diagnosis. In the case of grade 3 thyroid nodules, if there are no symptoms of hyperthyroidism and obvious compression in the front of the neck, regular follow-up observation is possible; if the thyroid nodule has already compressed the trachea, esophagus, etc., which affects the breathing and swallowing movements, minimally invasive surgical treatment is mostly recommended, and the nodule will be resected. After a small amount of thyroid tissue has been removed, thyroid function can often return to normal; after a large amount of thyroid tissue has been removed, patients will develop hypothyroidism after the surgery and will need to take thyroxine tablets for lifelong treatment. Patients with three types of thyroid nodules are advised to go to the endocrinology department of a regular medical institution and take reasonable treatments according to the doctor’s advice, so as to avoid delaying the condition and causing serious consequences.