Extreme dryness of the hands may be associated with vitamin deficiencies and keratosis pilaris, which can usually be dealt with through dietary supplements and medication. 1. Vitamin deficiency: Vitamin B2, C, niacin all help to maintain the health of the skin and mucous membranes, if there is a deficiency, the patient may experience extreme dryness of the hands. For this situation, patients can supplement through diet, adjust the dietary structure, pay attention to dietary balance, help to improve the patient’s dry hands, if necessary, oral multivitamins to improve. 2. Keratosis pilaris: If the hands are infected by fungi, keratosis pilaris will be induced, and the patient’s hands will be prone to extreme dryness. In this case, patients can usually apply antifungal cream, such as miconazole nitrate cream, terbinafine hydrochloride cream. There are other reasons for extreme dryness of the hands, and it is recommended that patients go to the hospital in a timely manner to identify the cause of the disease and then carry out standardized treatment, so as not to delay the condition.