The pain that manifests itself when the breast is touched prior to menstruation is considered to be related to edema of the breast follicles or soft tissues. This is because during the premenstrual period, the hormone levels in the body reach their peak, that is, the levels of estrogen and progesterone are too high, which can lead to edema of the tissue cells and manifest as breast swelling and pain, so it can also manifest as significant swelling. Patients may also suffer from palpitations or insomnia, which is caused by endocrine disorders. It is a common manifestation to take care of rest and not to exert oneself during the premenstrual period. Some patients may have a combination of breast enlargement, and this symptom will be more severe. Especially in middle-aged patients, who usually have a long history of the disease, nodules as well as masses of hyperplasia may also form. If necessary, medication should be given, including drugs to regulate microcirculation, activate blood circulation and remove blood stasis, mainly Chinese medicines, such as Breast Nucleus Dispersal Tablets and Plus Flavor Easy Pill.