Platelet count 465×10^9/L is higher than normal, and the normal reference range is (100-300)×10^9/L. Higher platelet counts need to be taken seriously and are generally more serious. Thrombocytosis mainly includes primary thrombocytosis and secondary thrombocytosis due to infection, acute blood loss, malignant tumor, anemia and so on. 1. Primary thrombocythemia: due to clonal proliferation of hematopoietic stem cells leading to abnormally high platelet count, platelet count persistently ≥450×10⁹/L, often accompanied by dizziness, fatigue, hemorrhage, thrombosis, splenomegaly, etc., which may lead to habitual abortion, cerebral hemorrhage, myocardial infarction, pulmonary embolism, and other complications, and in serious cases, may be life-threatening. 2. Secondary thrombocytosis: common causes include infection, acute blood loss, malignant tumor, anemia, post-splenectomy, etc. These diseases may lead to shock or even life-threatening in severe cases, and need to be actively treated for the causes. For example, infection requires antibiotic treatment, acute blood loss requires timely hemostasis and blood replenishment, and malignant tumors require surgery, radiotherapy and chemotherapy combined treatment. Patients with platelet count of 465×10^9/L are advised to consult a doctor in time to identify the cause of the disease and treat it actively.