According to the World Health Organization (WHO), in the 21st century, infertility will become the third largest disease in the world after tumors and cardiovascular diseases, especially male infertility patients have become more and more, so we suggest that infertile couples must be both together to check. There are many causes of infertility and the mechanisms are complex. Only after a scientific and comprehensive examination can the cause of infertility be determined and an effective treatment plan be formulated. Repeated semen tests for men and ultrasounds and hormone tests for women are inevitable. Male Infertility 10 Steps to Examine 1. Testicles: are the factories that produce sperm, if the testicles are underdeveloped and other acquired diseases, it can lead to infertility. We often perform a male examination to determine the volume of the testicles and to check whether they are well developed. 2, seminal vesicles, vas deferens: seminal vesicles and vas deferens are important vessels for transporting and storing sperm, and inflammation, adhesion and obstruction can lead to infertility. 3, semen: oligospermia, azoospermia, necrospermia, low sperm viability, poor motility, sperm deformities, poor semen liquefaction and so on, are the main causes of male infertility. The quality of sperm is directly related to fertilization, so semen routine is a must-do test for infertility patients. 4, urethra: urethra inflammation or bacterial viral infection, etc., pathogens will directly or indirectly affect the quality of sperm, resulting in infertility. 5, epididymis: is connected to the vas deferens and testes and storage of mature spermatozoa, pathogens microbial erosion, inflammatory reaction or other diseases can lead to infertility. For example, seminal plasma elastic scleroproteinase is an indicator of inflammation. 6, prostate: prostate fluid accounts for 30% of semen, and the prostate is an important part of providing nutrients for sperm. Inflammation and infection will cause low sperm viability, poor motility, oligospermia, dead sperm, poor liquefaction and other problems, resulting in infertility. Therefore, fingerprinting of the prostate gland and laboratory tests of prostate fluid are also indispensable. 7, ejaculatory dysfunction: common ejaculatory dysfunction such as non-ejaculation, retrograde ejaculation, semen can not be ejaculated from the urethra, resulting in infertility. 8.Sexual dysfunction: male sexual dysfunction such as an erectile fistula, premature ejaculation and so on, so that the sperm can not be normally shot into the depths of the vagina of women, resulting in the wife can not get pregnant. 9, sex hormones: sex hormone level imbalance, androgen reduction, resulting in spermatogenic dysfunction, so that sperm can not be produced normally, resulting in failure to conceive. Sex hormone is a further examination of semen abnormality and the cause of infertility. 10, immune factors: semen antigenic substances and the human immune system to produce adverse reactions, the emergence of anti-sperm antibodies, resulting in infertility. Immune infertility patients are not few. Female infertility 11 step check 1, ovaries: is the production of eggs, ovarian dysplasia, inflammation, Xiang Xiang, polycystic ovary syndrome, etc. can affect the production and development of eggs, leading to infertility. 2, the uterus: is the cradle of pregnant women to conceive babies, fertilized eggs to be in the bed here, and develop into a fetus. Many women suffer from infertility or spontaneous abortion due to problems such as inflammation of the uterine cavity, adhesions, endometriosis and uterine dysplasia. 3.Tubal: It is the only channel to transport eggs and the place where sperms and eggs are combined. Infertility or ectopic pregnancy is caused by tubal inflammation, adhesion, obstruction and so on. Therefore, tubal imaging or fluid passage is a must-do test for infertility patients, especially those with a history of abortion or spontaneous abortion. 4, cervical opening: is the first gateway for sperm to enter the uterus, if tumor, inflammation, erosion or other infections, resulting in cervical blockage, deformation and so on, making pregnancy failure. Gynecological examination seems simple, but in fact essential, cervical lesions can be observed through the naked eye first, if you want to further improve the examination, it can be through the gonorrhea, cervical scraping and so on. 5, vagina: vaginal urethra inflammation and infection, inflammatory cells and pathogens will directly or indirectly affect the quality of sperm, leading to infertility. Therefore the condition of leukorrhea should also be closely watched. 6, ovulation disorders: women’s hypothalamus – pituitary – ovary axis dysfunction, umbilical adhesion and other aspects of the problem, resulting in abnormal ovulation, can also lead to infertility or ectopic pregnancy. Follicular development does not mean that the follicles can be discharged normally, so it is necessary to perform ultrasound several times to monitor ovulation. 7.Pelvic cavity: Pelvic cavity inflammation, infection and other chronic diseases can cause reproductive organs lesions, dysfunction, and affect conception. Sex hormone: abnormal levels of sex hormone can cause endometrial dysplasia, ovulation disorders, and infertility due to the lack of egg implantation. Sex hormone can confirm the diagnosis of premature ovarian failure, polycystic ovary syndrome, hyperprolactinemia and other diseases that lead to infertility. 9, endocrine: thyroid, adrenal gland and other functional abnormalities, endocrine disorders, so that women’s menstrual irregularities, ovulation disorders, amenorrhea and other causes of infertility. 10, immune factors: there is a part of the couple, they are through the examination, reproductive organs, everything is normal, but just not pregnant, through the examination, found to be the production of anti-sperm antibodies, anti-ovarian antibodies, anti-cardiolipin antibodies, anti-hyaline antibodies and other adverse immune reactions, this immune response will kill sperm or inhibit sperm and egg combination, resulting in the inability to get pregnant. The lack of closed antibodies in a woman’s body can lead to spontaneous abortion. 11.Systemic factors: some women have abnormal fertility due to various reasons such as weak body, malnutrition, after-effects of abortion, habitual abortion and so on. The causes of infertility are numerous, plus women are in different menstrual cycles when they visit the doctor, and some tests can only be done at a specific time, often need to come and go to the hospital many times. And auxiliary tests are indispensable, so the treatment of infertility is not a short-term process, and requires patience as well as the cooperation of both doctors and patients.