A negative neocoronavirus antigen test may be followed by a positive nucleic acid test. A negative antigen test does not completely rule out the possibility of neocoronavirus pneumonia and is not a substitute for a nucleic acid test, as false negatives or false positives can occur during antigen testing. Negative antigen results can be monitored closely, and antigen or nucleic acid testing can be repeated if needed. For symptomatic patients, a visit to the fever clinic is recommended. In the case of a positive antigen test, nucleic acid testing is required for review. Timely control is also needed, regardless of respiratory or febrile symptoms, and should be reported immediately to the community in which they live for home isolation to avoid confirmation of the diagnosis leading to transmission of the virus. People who have close contact with confirmed patients with novel coronavirus pneumonia need to be isolated for observation and undergo multiple nucleic acid tests. The general population should take protective measures when going out to avoid the risk of being infected. Note: The terms “new coronavirus pneumonia” and “new coronavirus pneumonia” mentioned in this article were renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.