The chance of pathologic jaundice entering the brain is related to a number of factors and needs to be determined by a combination of the patient’s conditions. 1. Children: For children, the chance of jaundice entering the brain is mainly related to age, the level of jaundice, and the status of underlying diseases. The younger the child is, the higher the jaundice level is, the poorer the underlying disease status is, the higher the unconjugated bilirubin level is, and the more imperfectly the blood-brain barrier is developed, the more unconjugated bilirubin can not be prevented, and the higher the chances of jaundice entering the brain, resulting in the dysfunction of the central nervous system. 2. Adults: For adults, the so-called pathologic jaundice into the brain, i.e. hepatic encephalopathy, is mainly related to the degree of liver failure and cirrhosis. It is mainly related to the degree of liver function failure and the degree of liver cirrhosis, i.e., it is mainly due to the failure of hepatocyte function, and when the failure of hepatocyte function is more serious, the chance of jaundice entering the brain is greater, and it is more prone to hepatic encephalopathy and the prognosis is poor. When the patient appears pathological jaundice, timely hospital consultation, under the guidance of the doctor for examination and treatment.