Whether the condition of Lupus erythematosus patients is serious or not cannot be generalized, but needs to be analyzed in conjunction with the patient’s condition control, disease type and other factors. If the patient has cutaneous lupus erythematosus, the condition is usually not serious; if the patient has systemic lupus erythematosus, the condition is more serious. Lupus erythematosus is mainly categorized into cutaneous lupus erythematosus and systemic lupus erythematosus. Both types of lupus erythematosus are characterized by facial erythema, but cutaneous lupus erythematosus mainly affects the skin of the patient and seldom affects internal organs, so it is generally not a serious illness; systemic lupus erythematosus can involve multiple systems and organs besides the skin of the patient, and the illness is prone to recurrence, which makes the condition more serious in comparison. The prognosis of most skin-type lupus erythematosus is relatively good after timely and standardized treatment, and the survival period of most SLE patients is quite good after active treatment, while patients with severe and critically refractory SLE may suffer serious damage to the affected organs and endanger their lives if they are not treated in time, resulting in a poorer prognosis. It is recommended that lupus patients go to the rheumatology and immunology departments of regular hospitals for timely consultation and standardized diagnosis and treatment according to the doctor’s instructions.