Patients with breast nodules are generally eligible for the third dose, but if the nodules are malignant and undergoing radiotherapy, vaccination may be withheld. Currently, breast nodules are not a contraindication to vaccination and there is no clinical evidence that breast nodules pose a risk to vaccination with the new crown vaccine. Clinical data to date have not demonstrated that the vaccine causes or exacerbates the symptoms of breast nodules. Therefore, patients with breast nodules can receive a booster shot. However, if the nodules have worsened and are undergoing treatment such as radiotherapy, consult a healthcare professional to determine the effect of the medication on the New Crown vaccine, and withhold the vaccination if it is contraindicated. After the third vaccination, the patient should be observed in the observation room for thirty minutes to make sure that there are no symptoms of vaccine allergy such as localized skin redness, swelling, fever, dizziness, and so on, and then leave the room. Three days after vaccination, eat a light diet, no smoking and no alcohol.