Diabetic peripheral neuropathy is one of the three most common complications of diabetes mellitus, and the disease is insidious in its onset and can precede the onset of diabetic symptoms. Diabetic peripheral neuropathy is characterized by early involvement of sensory nerves, with painful numbness in the limbs as a prominent feature. Clinical manifestations are mainly peripheral nerve symptoms, bilateral or unilateral, symmetrical or asymmetrical limbs, but symmetrical damage is more common, the lower limbs are heavier than the upper limbs, abnormal sensation at the extremities, with the sensation of stepping on cotton pads, numbness ankylosis, etc. It is manifested as glove and sock-like sensory impairment with pain, numbness, coldness, weakness and muscle atrophy, which seriously affects the sensory and motor functions of the patient’s extremities. As the patient’s sensation is diminished or lost, especially no awareness of cold, hot and painful stimuli, it sometimes leads to very dangerous situations. For example, the patient’s foot injury occurs when the foot steps on a foreign object but does not feel the pain and will not be detected in time, or after hot water burns, but does not know. And some patients have obvious pain and often wake up in pain and have difficulty sleeping, which seriously affects the quality of life of patients. As patients have difficulty sleeping, the lack of sleep affects the quality of life, fatigue and fatigue, and the mood causes irritability or depression. However, it worsens as the disease progresses. Diabetic peripheral neuropathy can involve the motor nerves and may result in hypotonia, muscle weakness, muscle atrophy and paralysis, hyperactive Achilles tendon and knee tendon reflexes in the early stages and hypo or absent in the late stages, and diminished or absent vibration, perception, warmth and position sensation. Clinically, some patients with autonomic neuropathy experience dizziness, panic, blackness in front of the eyes, tinnitus, or even fall or confusion and other signs of insufficient blood supply to the brain, due to lesions of the nerves innervating the heart; and when lesions of the autonomic nerves innervating the gastrointestinal tract occur, they lead to nausea and vomiting, bloating and abdominal pain after eating, belching, indigestion, or alternating diarrhea and constipation, intestinal obstruction, etc.; when lesions of the autonomic nerves of the urinary When the autonomic neuropathy of the reproductive system is affected, the patient may experience dyspareunia, oliguria, incomplete urination, urinary retention, and easily complicate urinary tract infections, while the neuropathy of the reproductive system is manifested as male hypersexuality and impotence; some patients may experience less sweating at the ends of the extremities, accompanied by excessive sweating in the trunk area due to the lesion of the sweat nerves of the skin. The brain nerves may be affected by facial palsy, droopy eyelids, blurred vision and other symptoms. Patients with these symptoms need to be alerted and can undergo neuromyography. If subclinical nerve damage is found, early treatment can be provided to avoid delays. The most important thing in treating diabetic peripheral neuropathy is to control blood sugar, in addition to improve microcirculation, improve the blood supply and oxygen supply to nerve cells, which can promote the repair and regeneration of damaged nerve cells. Use some blood activating and nerve nourishing drugs, such as vitamins and nerve growth factor, to cooperate with the treatment.