Clotrimazole vaginal swelling suppositories should be removed after 24 hours and should not be left in place for too long. If they are left in place for too long, they can easily lead to infection, which may cause vaginal inflammation and even upstream infection, which can cause pelvic inflammatory disease in women. The main ingredient of clotrimazole vaginal expansion pessary is clotrimazole, which is used for the treatment of Candida vulvovaginosis. This drug is administered vaginally, and the pessary is usually placed deep in the vagina after washing the perineum.