Swollen, hard and painful nose may be caused by boils, folliculitis and nasal vestibulitis, which can be treated with anti-inflammatory and pain-relieving topical medications under doctor’s supervision. 1. Boil: It is usually a bacterial infection caused by pathogenic bacteria such as Staphylococcus aureus and manifests itself as a red, swollen, hot and painful nodule, which will gradually become bigger and bigger, with yellowish-white pus coming out from the top. Mupirocin ointment can be used to apply to the lesion to promote its subsidence. 2. Folliculitis: Folliculitis is a very common skin disease, usually considered a bacterial infection, may also appear red, swollen and painful symptoms. Patients can use fusidic acid cream, clindamycin gel and other external application. 3. Nasal vestibulitis: generally due to bad nose picking habits, pulling nose hairs and other factors, inflammation stimulation of the nasal vestibule skin caused by infection. The main manifestations are pain, redness, swelling, itching and so on in the nasal vestibule, and in serious cases, there will be erosion or cracks. Sulfathiazole ointment can be used to relieve the symptoms. Avoid bad nose picking habits, should be under the guidance of the doctor reasonable and standardized medication.