Interstitial fibrosis is a group of diffuse diseases that involve the alveolar cavities and interstitium, causing loss of alveolar-capillary functional units. 1. Causes and manifestations: Interstitial fibrosis is related to radiation, dusty occupational environment, drugs, long-term smoking, connective tissue diseases (rheumatoid arthritis, ankylosing spondylitis, etc.), etc. Clinically, it is mainly manifested by symptoms such as tightness in the chest, dyspnea, dry cough, chest pain, etc., and it can also be manifested by non-specific manifestations such as loss of appetite and cyanosis. 2. Diagnosis: The diagnosis can be made by perfecting pulmonary function test, high-resolution CT of chest, bronchoscopy, biochemical examination or pathological examination of tissues under thoracoscopy under the advice of doctor, and combining with clinical manifestations. 3. Treatment: Pirfenidone anti-fibrosis, dextromethorphan hydrobromide syrup to stop coughing, silicosis tablets to clear heat and resolve phlegm can be used under doctor’s guidance, and antibacterial drugs such as azithromycin can be used according to the situation. Patients with interstitial fibrosis need long-term low-flow oxygen to improve hypoxia. If conditions permit, lung transplantation is feasible, which can improve the patient’s quality of life and prolong life. Interstitial fibrosis is a chronic progressive disease, and the condition will gradually deteriorate over time. If you have chest tightness, dyspnea and other discomforts, it is recommended to consult a doctor as soon as possible and follow the doctor’s instructions to standardize the treatment.