Apatinib is mainly used to treat advanced gastric adenocarcinoma or adenocarcinoma of the gastric and esophageal junction. There are various side effects that may occur after the use of Apatinib, mainly including weakness, headache, dizziness, diarrhea, loss of appetite, fecal occult blood, vomiting, abdominal pain, nausea, gastrointestinal bleeding, hoarseness, increased blood pressure, hand-foot syndrome, proteinuria, hypoproteinemia, hypokalemia, hypophosphatemia, leukopenia, granulocytopenia, thrombocytopenia, decreased hemoglobin, decreased red blood cells, and there may cause elevated hepatic transaminases, elevated total bilirubin, elevated alkaline phosphatase, and elevated transaminases. What must be of special concern when using the medication are elevated blood pressure, proteinuria, hand-foot syndrome, bleeding, cardiotoxicity, hepatotoxicity, etc. It is important to pay attention when using the medication and to consult the doctor promptly for any abnormal performance and adjust the medication in a timely manner.