The medications that can be taken for dry syndrome generally include non-steroidal anti-inflammatory drugs such as diclofenac sodium, immunologic agents such as methotrexate, glucocorticosteroids such as prednisolone, and biologic agents such as rituximab. Specific medication is recommended to follow the doctor’s prescription. Dry syndrome is a chronic autoimmune disease, in addition to dry mouth, dry eyes and other symptoms will cause damage to related organs. Currently there is no cure, the main goal is to improve symptoms, control and delay tissue and organ damage and prevention of infection. 1. Non-steroidal anti-inflammatory drugs: such as diclofenac sodium, celecoxib, etc., used to treat patients with joint and muscle pain. 2. Immunological agents: commonly used are hydroxychloroquine sulfate, methotrexate, azathioprine and cyclophosphamide, etc. Hydroxychloroquine sulfate can be chosen for non-systemic involvement, while cyclophosphamide and azathioprine can be chosen for systemic involvement, especially when neurological complications occur, and close testing of blood counts and liver and renal functions are needed after taking the drugs. 3. Glucocorticosteroids: such as prednisolone, dexamethasone, etc., are suitable for patients with desiccation syndrome with neurological complications, glomerulonephritis and interstitial lung disease, and the dosage should be decided according to the severity of the disease. In addition, dry syndrome can also be treated with biologics such as rituximab, which is suitable for patients with dry syndrome with severe arthritis, hematopenia and peripheral lesions. It is recommended that patients with dry syndrome consult a doctor in time, use medication under the guidance of a physician, and avoid self-medication.