The question of whether it is possible to take amoxicillin without roxithromycin depends mainly on the type of pathogen causing the infection. Clinically, anti-inflammatory treatment with roxithromycin is generally used. Commonly, there are inflammation of the respiratory tract, such as bronchitis, pneumonia, acute upper respiratory tract infection, etc. Commonly, there are purulent bacterial infections, mainly Gram-positive bacteria, and at this time, amoxicillin can be used instead of roxithromycin, and the effect is also good. However, if it is clear that the inflammation of the respiratory tract is caused by mycoplasma and chlamydia infections, amoxicillin cannot be used instead of roxithromycin because these pathogens are sensitive to macrolides and can be inhibited and killed, and the use of amoxicillin is ineffective.