Soreness at the base of the right thumb may be caused by physiological factors such as long-term compression; it may also be caused by trauma or tenosynovitis. 1. Physiological factors: If the root of the right thumb is subjected to long-term pressure or stimulated by cold air for a long period of time, symptoms such as soreness and numbness may occur. 2. Trauma: If the right thumb is overused or if the hand is suddenly subjected to strenuous exercise, it may result in sprains of the fascia and soft tissues of the right thumb or even a fracture of the right thumb phalanx, which may lead to symptoms such as soreness and swelling of the root of the right thumb. 3. Tendovaginitis: Tendovaginitis may be induced by traumatic stimulation of the right thumb and chronic strain injury, resulting in soreness at the root of the right thumb, which may be accompanied by pain on pressure and restriction of the right thumb’s movement. If the right thumb root pain, after excluding physiological factors, we recommend that the patient go to the hospital to clarify the cause of the disease, and then follow the doctor’s instructions as soon as possible for treatment.