Usually there is no difference between glomerular fibrosis and sclerosis, glomerular fibrosis is the pathological basis of glomerulosclerosis, and glomerulosclerosis is the end manifestation of glomerular fibrosis. Glomerular fibrosis can be divided into three phases, the first phase is the inflammatory response phase, in this phase the renal tissue has been damaged, but still in a compensatory state, usually there is no obvious manifestation, only a small number of patients will show glomerulosclerosis. The second stage is the fibrosis formation stage, at this time the renal function has entered the uncompensated stage or even renal failure, at this time, if the treatment is actively carried out, the progress of the disease can be slowed down. The third stage is the scar formation stage, in this stage, the kidney damage is irreversible, and the main treatment at this time is dialysis treatment. If patients find that the kidney function is impaired, it is recommended to go to regular hospitals in time, and standardize the treatment under the guidance of doctors.