Chronic pharyngitis with follicles is formed when inflammatory factors stimulate the mucosa of the throat wall and the submucosal connective tissue, which leads to the proliferation of lymphatic tissue. Chronic pharyngitis with follicles is generally not a routine factor in determining whether cancer is present, while the cause of the disease is often the main reference for the likelihood of cancer. Common factors that cause cancer in the throat include smoking, malnutrition, viral infections and so on. 1. Smoking: Benzo(a)pyrene in tobacco tar produced when tobacco is burned is carcinogenic, and smoking can lead to chromosomal aberrations. Most of the patients with laryngopharyngeal cancer have long-term smoking history, and the amount of smoking is large, and many of them also abuse alcohol at the same time. Wine can not only stimulate mucosa and induce mucosal epithelial dystrophy, but also promote the carcinogenic effect of smoke. 2. Malnutrition: ischemic anemia often leads to mucosal changes in the laryngopharynx, such as mucosal thinning, mucosal epidermal pegs in the hair layer disappear, intracellular glycogen is reduced or lacking, pharyngeal and esophageal mucosa is widely atrophied, and swallowing is difficult. 3. Viral infection: under certain conditions, EB virus and human papilloma virus may cause cancerous changes in the mucosa of pharynx. 4. Other factors: lack of certain vitamins or trace elements, certain industrial or occupational damages, environmental pollution and so on, may become cancer-promoting factors. Chronic pharyngitis with follicles, it is recommended to consult the doctor as soon as possible, and follow the doctor’s instructions to standardize the treatment.