Amoxicillin can treat otitis media. Otitis media is a clinical manifestation of fluid accumulation in the middle ear cavity caused by an acute upper respiratory tract infection. The pathogenic bacteria are Streptococcus haemolyticus and Staphylococcus aureus, which travel retrograde through the eustachian tube and cause fluid accumulation in the middle ear cavity, resulting in severe pain in the ear and hearing loss. If the inflammation worsens, it can lead to perforation of the eardrum. Usually, the perforation is in the tense part of the tympanic membrane. On examination, a pus and blood discharge from the external ear canal and hearing loss are seen. Because it is a hemolytic streptococcus, which is sensitive to cephalosporins, oral cefixime or amoxicillin is given. Topical oxyfloxacin ear drops with 2 times/day irrigation will heal in about a week. After healing, you need to exercise and avoid colds to be able to avoid recurrence.