Reticular fiber staining grade 0-1 is normal. Reticular fibers are mainly distributed in bone marrow, spleen, liver, lungs, lymph nodes and other tissues, reticulofibrillar staining mainly refers to dyeing reticulofibrillar fibers in black by silver immersion method, which can show reticulofibrillar fibers in relevant examinations, help to determine whether collagen fibers and reticulofibrillar hyperplasia are present in various tissues, and differentiate the nature and source of the tissue tumors. Normal reticulofibrillar staining grade 0-1 means that the part examined has no fibroplasia, fibrosis or a small amount of reticulofibrillar hyperplasia, which is focal or patchy. When reticulofibrillar staining exceeds grade 1, it may represent the presence of diffuse proliferation of fibers, usually in a reticular pattern, with sclerosis, fibrosis, and dilatation of the blood sinuses. As myelofibrosis may cause a lack of hematopoietic cells when it is severe, and there may be the appearance of new bone due to the dense reticular fibers, the patient should go to the hospital in time to clarify the cause of the disease and then carry out systematic treatment under the guidance of the doctor.