Liver distension and pain after drinking is mostly caused by alcohol damage to the liver, lesions of the liver itself and gallbladder-related diseases. 1. Alcohol damage to the liver, alcohol metabolism in the body after the product will damage liver cells, resulting in liver cell damage, inflammation, edema and other manifestations, and then stimulate the hepatic peritoneum, swelling and pain. 2. Liver lesions, if you suffer from liver diseases, such as cirrhosis, hepatitis, liver tumors and other diseases, drinking alcohol will also stimulate the liver swelling and pain. 3. Gallbladder-related diseases, because the gallbladder is adjacent to the liver, so when there are chronic cholecystitis, gallbladder stones and other diseases, it is also possible to experience swelling and pain after drinking alcohol. It is recommended to consult a professional doctor in a regular hospital.