Large areas of peeling skin on the hands if caused by ringworm can be used antifungal drugs, if caused by exfoliative keratolysis can be used emollients, if caused by eczema can be used hormones. 1. Ringworm: If there is a fungal infection on the hands, there will be peeling, there will be itching and other symptoms, you can use ketoconazole cream, terbinafine cream and other antifungal drugs. 2. Exfoliative keratolysis: often can be manifested as repeated episodes of scaling, peeling, generally self-healing, you can use emollients such as petroleum jelly and other relief. 3. Eczema: if there is eczema, there will be peeling phenomenon, at the same time there will be erythema papules and other manifestations, you can use glucocorticosteroids such as Dinaid cream relief. If the peeling of the skin on the hands is serious, go to the hospital in time to check, use the above drugs should follow the doctor’s instructions.