High uric acid can be inherited. 10%-25% of gout patients in China have a family history of gout, and 10%-20% of close relatives suffer from hyperuricemia. The metabolism of purines in the human body requires the participation of various enzymes. When genetic defects or abnormalities occur, the enzymes do not function properly and the purines are metabolized abnormally, leading to hyperuricemia. There are two possible causes for hyperuricemia and gout, one is genetic and the other is environmental. People in the same family have similar diet and lifestyle habits, and environmental factors include common diet and lifestyle habits, while common types of genetic factors include X-linked recessive inheritance, autosomal recessive inheritance and polygenic inheritance. Therefore, it is recommended that the offspring of patients with hyperuricemia or gout be examined regularly as adults to prevent it earlier.