Wake up in the morning chest pain may have three main situations: First, physiological pain, due to sleep at night posture is not correct, caused by the breast or local chest wall tissues for a long time pressure, resulting in blood circulation obstacles and thus lactic acid stagnation, wake up chest pain discomfort is a normal physiological phenomenon, do not need to be special treatment. Second, peptic ulcer, due to the vagus nerve excitation leads to excessive secretion of gastric acid, resulting in peptic ulcer symptoms after getting up, manifested as post-sternal pain and can be accompanied by abdominal distension and ergonomic discomfort. Third, the heart system diseases, such as coronary heart disease or myocardial infarction, easy to wake up in the morning after the sympathetic nerve excitation, resulting in coronary artery contraction of severe pain in the anterior thoracic area, oral nitroglycerin pain can be slightly relieved. There are many kinds of diseases that cause chest pain in the morning, we should go to regular hospitals to do gastroscopy or electrocardiogram to make a clear diagnosis, and carry out reasonable treatment under the guidance of specialists.