Depending on the cause of the pimples around the mouth, lifestyle improvement, oral medication and topical medication are used. However, do not squeeze the pimples around your mouth with your hands. The causes of pimples around the mouth can be categorized as herpes simplex, folliculitis, and acne. 1. Herpes simplex. This disease is easy to recur, and commonly occurs when the body’s immunity is reduced. At this time, you should adjust your work routine to minimize late nights, and take antiviral drugs such as acyclovir orally to treat it. 2. Folliculitis. It may be related to bacterial infection, you should pay attention to the skin around the lips and mouth clean, to reduce the breeding of bacteria, but also in the doctor’s guidance of external use of drugs such as mupirocin treatment. 3. Acne. Acne is caused by excessive oil secretion during puberty, patients should pay attention to rest, reduce hormone fluctuations, pay attention to facial cleansing, and can be treated with topical adapalene, benzoyl peroxide gel and other drugs. It is important to note that regardless of the cause of acne around the mouth, do not use your hands to squeeze, so as not to allow pathogenic microorganisms to invade the danger triangle caused by serious infections, as well as timely access to the doctor, follow the doctor’s instructions for treatment.