Toothache may be a physiological factor or a pathological factor such as caries, periodontitis, pulpitis, etc. Different etiologies lead to different treatments, and the methods for relieving toothache include improvement of lifestyle, medication, and surgical treatment. However, surgical treatment should be the main treatment. 1. Improve lifestyle: For toothache caused by physiological factors, such as poor living habits, not paying attention to oral hygiene, eating too sweet and too acidic food, mental stress, etc., it is recommended that patients pay attention to oral hygiene, and practice oral hygiene. It is recommended that patients pay attention to oral hygiene, proper brushing, avoiding long-term over-eating of stimulating foods, maintaining a positive mindset, and playing appropriate sports to enhance physical fitness. 2. Medication: For toothache caused by caries, you can use 75% sodium fluoride glycerin paste, 8% stannous fluoride solution and other drugs to relieve toothache. For toothache caused by periodontitis, you can use metronidazole, tinidazole, doxycycline and other drugs to relieve pain. For toothache caused by pulpitis, you can use acetaminophen, ibuprofen and other drugs to relieve pain. 3. Surgical treatment: If caries is more serious, surgical filling, such as inlay restoration, amalgam filling, etc. is needed. If the periodontitis is more serious, it is necessary to perform bone grafting, flap surgery, dental implant surgery and other surgical treatments. For toothache caused by pulpitis, surgical treatment can be performed to relieve the pain, such as root canal surgery, indirect pulp capping, pulpotomy and so on. When patients have toothache, after excluding physiological factors, they should go to the hospital in time to find out the cause of the disease and then treat it. The above medications should be used under medical supervision.