Pain in the liver is not necessarily a precursor to self-healing hepatitis B. Pain in the liver area is mostly caused by the involvement of the liver envelope. An enlarged liver can cause pain in the liver area, and the shrinking of an enlarged liver during recovery from liver disease can also involve the envelope and cause vague pain in the liver area. Patients with hepatitis B who have severe pain in the liver area should consider other complications, such as liver cancer. People infected with hepatitis B virus are at high risk for liver cancer. If liver pain occurs, liver and biliary ultrasound and methemoglobin examination should be performed as early as possible to exclude liver cancer. In addition, if active hepatitis is present, stimulation of sensory nerves on the liver envelope may also cause vague pain in the liver area. Other diseases such as cirrhosis, cholecystitis, and gallbladder stones may also cause pain in the liver area. Therefore, pain in the liver area is not necessarily a sign of self-healing of hepatitis B, but may also be a sign of aggravation of the disease. Patients with hepatitis B who experience pain in the liver area should actively visit a hospital department such as hepatology or gastroenterology for a clear diagnosis and cooperate with the doctor for treatment to prevent aggravation of the disease.