Glutamyltransferase is mainly present in the liver cell membrane and microsomes and is involved in the metabolism of glutathione. The reasons why glutamyl transferase may be increased in serum and the treatment methods are as follows: 1.If there is drinking, staying up late or eating too much high protein food before the examination, it will increase the burden on the liver and lead to a mild elevation of glutamyl transferase, which can generally be relieved by removing the triggers and taking sufficient rest; 2.If there is intrahepatic or extrahepatic bile duct obstruction, or due to diseases such as bile duct stones and biliary tumors, which make glutamyl If the bile duct obstruction is intrahepatic or extrahepatic, or due to bile duct stone, bile duct tumor or other diseases, the excretion of glutamyltransferase is obstructed, and it will return to blood with bile, which will cause high serum glutamyltransferase. The bile duct obstruction can be removed surgically or treated by endoscopic choledochotomy for gallstones; 3. Liver injury can be treated with drugs such as diammonium glycyrrhetinate enteric capsule, glutathione, compound glycyrrhetinic acid tablets for anti-inflammatory and hepatoprotective treatment, and application of potassium magnesium menthylate and ursodeoxycholic acid to promote hepatocyte repair. Besides liver and bile duct diseases, pancreatitis and prostate tumor can cause elevated glutamyl transpeptidase. Patients should seek medical attention in time to make differential diagnosis through perfect examination so as to formulate corresponding treatment measures.