Glutamate dehydrogenase is found mainly in the mitochondria of liver, kidney and brain tissue cells, and is most abundant in the liver, where it helps regulate human metabolism. Therefore, glutamate dehydrogenase is often tested in biochemical blood, and the level of the test indicates the degree of damage to liver cells. High levels may be due to dietary influences, but may also be due to disease. If a high value is found in the test, it is necessary to consult a doctor promptly and combine it with clinical symptoms and other related tests, such as hepatitis B five, ultrasound, CT, etc., to determine the cause. The common causes of high glutamate dehydrogenase are as follows: a. External factors: the presence of a history of alcohol consumption before the test, or eating too greasy food, such as barbecue, hot pot, fatty meat, fried food, etc., can affect the value of glutamate dehydrogenase test, resulting in a slight increase in glutamate dehydrogenase. If the above situation exists, it is recommended that the patient be retested in a timely manner. Second, disease factors: 1. Acute viral hepatitis: In addition to high glutamate dehydrogenase, test results can also be seen as increased glutamate aminotransferase, glutamic oxalacetic aminotransferase, total bilirubin and direct bilirubin. Patients may show symptoms such as weakness, decreased appetite, and vague pain in the right upper abdominal liver area. 2. Chronic hepatitis: including fatty liver and alcoholic liver, etc. Because glutamate dehydrogenase is widely present in liver lobules, when liver parenchyma is damaged, glutamate dehydrogenase is significantly elevated, which can reach 4-5 times the normal value, and elevated glutamate transaminase and glutamic oxalacetic transaminase are also seen. Patients may have symptoms such as fever, fatigue and pain in the liver area. 3. cirrhosis: the degree of elevated glutamate dehydrogenase depends on the degree of liver cell damage, and patients may show symptoms such as nausea, loss of appetite, postprandial bloating, diarrhea, gastrointestinal bleeding, etc., and may also show general weakness, yellow staining of the skin and sclera.