Surgery can be considered in the early stages of plasma cell mastitis when the lump is more confined. The treatment of plasma cell mastitis should be different according to the degree of periductal inflammation and breast ductal dilatation. Plasma cell mastitis is an autoimmune disease. Surgery is needed if medical treatment is ineffective or if the lump persists, and simple medical treatment is ineffective and cannot achieve the goal of cure. Surgery is required when an abscess forms and can rupture on its own and a breast lump appears, or when the nipple overflows with a thick, mucousy discharge and a fistula is formed, which can be treated with a localized lumpectomy. Patients usually present with a breast lump that is confined, or quadrant, hemi-mastectomy and total mastectomy may be used, and patients usually present with a large lump and a lesion that occupies the entire breast or most of the breast. Surgery for plasma cell mastitis should be based on the severity of the disease. Patients with mild disease can be treated with glucocorticosteroids and antibiotics as prescribed by the doctor. The daily diet should be light and less spicy and irritating food.