Whether total bilirubin 59umol/l with normal transaminases is serious or not depends mainly on the cause, if it is caused by physiological reasons, it is usually not serious, if it is caused by diseases, such as acute hepatitis, chronic hepatitis, etc., it may be more serious. Total bilirubin of 59umol/l is on the high side, but the aminotransferase is currently normal, it may be caused by physiological reasons, such as severe sleep deprivation, heavy drinking, excessive fatigue, etc. It is usually not serious, and after resting, the symptoms will gradually recover and the total bilirubin will return to normal. However, if the total bilirubin is persistently elevated and aminotransferase is elevated, it may be caused by abnormal liver function, for example, acute hepatitis or chronic hepatitis, etc., which often leads to repeated bilirubin elevation, which is more serious, and need to go to the hospital in time for medical consultation, otherwise it is likely to lead to further progress of the disease. It is recommended that when the total bilirubin is 59umol/l and the aminotransferase is normal, to go to the hospital in time, to exclude the physiological causes, and then receive timely treatment.