Hormone reduction in patients applying large amounts of hormone therapy needs to be gradual after the disease is under control. Prednisone acetate, for example, is usually reduced by 5 mg over 1 to 2 weeks. How to reduce the dosage should strictly follow the doctor’s instructions. Large doses of hormones are necessary for the treatment of many autoimmune diseases, but since long-term use of large amounts of hormones can lead to serious complications such as osteoporosis, femoral head necrosis, gastrointestinal bleeding, etc., they need to be tapered off gradually after the disease is under control. Hormones need to be reduced slowly, if the drug is stopped suddenly, it may lead to adrenocortical hypofunction, or even adrenocortical crisis. Take prednisone acetate as an example, after the disease is under control, it is slowly reduced, usually by 5 mg (1 tablet) in 1 to 2 weeks, and when the dose is reduced to less than 20 mg, it is necessary to reduce it more slowly, or even to maintain it at this dose for a period of time. The above dosage reduction method is only the general situation of the dosage reduction method, need to be adjusted by the doctor according to the individual’s condition, the patient should also strictly comply with the doctor’s instructions for the use of medication.