Tadalafil has no obvious therapeutic effect on prostate enlargement, and patients with prostate enlargement should choose appropriate and effective treatments under the guidance of their doctors. Tadalafil is mainly used for the treatment of erectile dysfunction in men, while prostatic hyperplasia is an aging disease related to androgen levels as well as aging, and patients may experience clinical symptoms such as frequent urination, difficulty in urination, and urinary retention. Patients with mild prostate hyperplasia can be observed without special treatment for the time being. Patients with severe conditions can be treated with alpha receptor blockers such as terazosin, doxazosin, tamsulosin, and 5 alpha reductase inhibitors such as finasteride and dutasteride. If necessary, open surgery or transurethral resection of the prostate is feasible. Adverse reactions such as headache, dyspepsia, and muscle pain can occur with tadalafil. Patients with prostate enlargement should strictly follow the doctor’s instructions to use medication, not blindly self-medication, in order to avoid serious adverse reactions, or delay the condition.