Causes of non-ovulation, first, central endocrine disorders. When the central endocrine disorder, the peak secretion level of luteinizing hormone is not enough to stimulate the biological, biochemical and histological changes that cause the follicle wall to be digested and ruptured, thus affecting the reproductive growth of the follicle and the occurrence of ovulation. Second, gynecological diseases. In pelvic inflammatory disease, for example, the fallopian tubes will thicken, fibrosis and stripes, and even adhesions to the ovaries, uterus, surrounding tracheal tissue, forming hard and fixed masses, which in severe cases will prevent ovulation. Third, enzyme deficiency and prostaglandin deficiency. Fibrinolytic enzymes, activated collagenase, and prostaglandins act on the basement membrane of the follicular wall, digesting the follicular wall and causing the formation of follicular ovulation holes. If the enzyme deficiency and prostaglandin deficiency are present at this time, the egg discharge will be greatly affected. Fourth, hyperprolactinemia. Prolactin affects the normal secretion of pituitary gonadotropin, which causes ovarian dysfunction and affects the normal development of follicles and ovarian ovulation. Fifth, psychological factors. Such as long-term stress, anxiety, panic and other stressful conditions can cause repeated small peaks in blood prolactin levels and affect ovulation, which are accompanied by symptoms such as irregular menstruation, dysmenorrhea and breast tenderness.