Blisters on the feet may be two cases, one is a fungal infection, a friction dermatitis, fungal infection is recommended to apply topical antifungal drugs, such as terbinafine cream, ketoconazole cream, etc.; friction dermatitis, it is recommended to reduce the friction, and if necessary, to pick, disinfected with medication. If the fungal infection with blisters may also be accompanied by itching, the infection area will gradually increase. It is recommended to wear breathable shoes and socks, keep the feet dry and clean, and use antifungal creams, such as terbinafine cream and ketoconazole cream. But if the shoes do not fit or walk too much, it will cause frictional dermatitis to form blisters. If the blisters are large, it is recommended that the blisters be opened and disinfected with iodophor, apply erythromycin for anti-infection treatment, and pay attention to wearing suitable shoes and reducing walking. It is recommended that the blisters on the feet should be treated promptly and in accordance with the doctor’s instructions.