Heartburn is commonly associated with gastroesophageal reflux disease (GERD), but it can also be physiologic, with different causes and different treatments. Frequent heartburn requires prompt medical attention to identify the cause of the disease. The symptoms of heartburn may be caused by pregnancy, overfeeding, irritating food, mental stress and other physiological factors. Generally, it can be relieved by changing the body position, such as maintaining an upright position after meals, etc. At the same time, it is necessary to pay attention to avoiding excessive intake of fat, avoiding overeating, controlling body weight, and paying attention to adjusting the mood, etc., which can effectively control the symptoms. Gastroesophageal reflux (GERD), gastritis, etc. may also be caused by GERD, which requires timely medical treatment, including medication and surgery. Heartburn caused by gastroesophageal reflux and gastritis can be treated with acid-suppressing drugs (omeprazole, etc.), gastrointestinal stimulants (domperidone, etc.), antacids (e.g., sodium bicarbonate, etc.), and mucous membrane protectants (aluminum thioglycollate, etc.). If necessary, surgical treatment can be considered, such as gastroesophageal reflux patients can use laparoscopic fundoplication and other surgical methods. If the symptoms of heartburn occur frequently or are accompanied by other discomforts, you should consult a doctor in time, complete the relevant examinations, clarify the cause of the disease, and then have the doctor carry out targeted treatment.