Positive RO52 antibody suggests that the patient’s immune system is impaired, and may suffer from rheumatic diseases, liver diseases, but the specific diseases need to improve the relevant examination. RO52 belongs to the autoantibody family and is an important indicator of whether a patient has a rheumatic disease. Positive RO52 antibodies indicate that the patient may have polymyositis, lupus erythematosus and other diseases. Although the most common disease that is positive for RO52 is dry syndrome, this indicator alone cannot determine which rheumatic disease the patient is suffering from, and other tests such as anti-SSA antibody and anti-SSB antibody are still needed. At the same time, RO52 antibody positivity also exists in the development of autoimmune liver diseases, such as viral hepatitis, primary biliary cirrhosis, etc. RO52 antibody positivity can be seen in the initial stage of the disease, and RO52 antibody negativity may occur during the recovery period of the disease.