Taking amlodipine benzenesulfonate in the morning and nifedda in the evening, this antihypertensive dosing regimen is usually inappropriate. Nifedat is nifedipine extended-release tablets, and amlodipine benzenesulfonate, both belong to the antihypertensive drugs in the calcium channel blockers, and similar antihypertensive drugs are not recommended to be used at the same time. When the blood pressure is not well controlled with a calcium channel blocker alone, a reasonable combination of drugs can be considered according to the condition of the patient, such as the joint use of β-blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, diuretics and so on. The patient’s baseline blood pressure, target blood pressure, current condition and other factors should be fully considered to avoid too low and too fast a drop in blood pressure. It should be noted that calcium channel blockers may cause adverse reactions such as headache, facial flushing, and ankle edema. Hypertensive patients must use medication under the guidance of a doctor and must not choose antihypertensive drugs on their own to avoid danger.