Antiepileptic drugs can be routinely given when leukemia induces seizures, which can be treated with sodium valproate, benzodiazepines, and gabapentin. The main causes of seizures are related to chemotherapy and stem cell transplantation. 1. Chemotherapeutic drugs: according to relevant reports, leukemia complication epilepsy is mainly due to chemotherapeutic drugs, but the causative factors are unknown. Seizure control may be achieved by applying antiepileptic drugs or lowering the dosage of chemotherapeutic drugs, including sodium valproate, benzodiazepine, gabapentin and so on. 2. Stem cell transplantation: It is also a cause of epileptic seizures, benzodiazepines are commonly used drugs. The development of seizures or chronic epilepsy in leukemia patients is a common neurological complication that can affect the patient’s prognosis. Therefore, there is a need to adjust the treatment regimen of leukemia and actively prevent seizures, which may improve the prognosis of patients. When epilepsy is induced in patients with leukemia, the treatment should be standardized according to the doctor’s prescription, and the above drugs need to be used under the guidance of the doctor to avoid blind self-medication.