Uremia for chronic kidney disease stage 5, glomerular filtration rate <15ml/(min-1.73m²) with dialysis indications when dialysis treatment is needed, if at this time the patient's urine output can be maintained normal without edema, weight stabilization, and there is no uremia signs and symptoms, the timing of dialysis can be delayed. 1. Indications for dialysis: pericarditis or plasmapheresis; uremic encephalopathy. Deteriorating nutritional status; persistent or refractory tax overload; severe fatigue and weakness; mild cognitive impairment; refractory acidosis, hyperkalemia and hyperphosphatemia. 2. Symptoms associated with uremia: fatigue, confusion, anorexia, nausea, altered sense of smell and taste, muscle cramps, restless legs, sleep disturbances, and pruritus; 3. Uremic signs: convulsions/altered convulsive threshold, amenorrhea, decreased central body temperature, protein-energy depletion, insulin resistance, increased catabolism, plasma membrane inflammation (pleurisy, carditis), eructation (hiccups), platelet dysfunction, lethargy, etc. Dialysis therapy can only replace part of the excretory function of the kidneys, but not the endocrine function and metabolic function of the kidneys. Renal anemia and renal hypertension should be corrected before the use of dialysis therapy, and the treatment should be carried out under the guidance of doctors. It is recommended that uremia patients should consult the hospital in time and follow the doctor's advice to choose the appropriate treatment.