Mash, also known as rice wine, is a kind of sweet rice wine fermented with steamed river rice mixed with wine fermentation. Although the alcohol content of rice wine is low, it can also have a disulfiram-like reaction with cephalosporin. Under normal circumstances, after drinking rice wine, the liver will convert alcohol into acetaldehyde, which will be converted into acetic acid with the help of the enzyme acetaldehyde dehydrogenase, and finally into water and carbon dioxide to be discharged from the body. However, the use of Cephalosporin will inhibit the function of acetaldehyde dehydrogenase and prevent the conversion of acetaldehyde into acetic acid, leading to the rapid accumulation of acetaldehyde in the body, which then triggers toxic reactions, such as flushing of the face, panic attacks, lowered or elevated blood pressure, fatigue, gibberish, tightness in the chest, and a sense of near death. It is recommended to avoid drinking alcohol during the use of Cephalosporin, and also avoid drinking alcohol within one week after the use of the drug to avoid triggering disulfiram-like reactions.