Facial twitching with a crooked mouth can be caused by epilepsy, cerebrovascular disease or facial neuritis. 1. Epilepsy: It is a brain dysfunction caused by abnormal discharge of neurons in the brain. Some partial seizures can start with facial muscle twitching, which can lead to facial twitching and crooked mouth symptoms. 2. Cerebrovascular diseases: for example, cerebral infarction, cerebral hemorrhage and other diseases may compress the nerves, resulting in facial twitching and crooked mouth, and most of them are accompanied by limb inflexibility and slurred speech. 3. Facial neuritis: for example, wind and cold, resulting in facial nerve paralysis, manifested in facial muscle contraction, abnormal motor function, mouth crooked, a small number of symptoms can also lead to facial muscle spasm. Facial twitching mouth crooked, there may be other reasons, need to go to the hospital in time to confirm the diagnosis and timely treatment.