The reason for sore palms after drinking alcohol is that blood circulation is accelerated throughout the body after drinking alcohol, and blood vessels dilate, especially in the hand as the end of the limb, resulting in blood congestion in the hand and causing hand swelling. The metabolism of the hand muscles and other soft tissues is accelerated, so the blood oxygen supply is correspondingly insufficient, and the anaerobic metabolism in the tissues increases and the aerobic metabolism decreases, leading to an increase in acidic metabolites such as lactic acid, which stimulates the nerves in the hands and causes sore palms. At the same time, alcohol is metabolized and decomposed by the liver in the body to produce acetic acid, which will also stimulate the tissues and nerves in the palm of the hand when circulating to the palm of the hand through the blood, resulting in local soreness. By drinking a lot of water to speed up urination and applying local cold compresses, palm pain symptoms can be significantly relieved.