The two testicles are not the same size may be physiological factors, may also be the manifestation of certain diseases, such as testicular inflammation, testicular syringomyelia, etc., should be timely consultation to identify the cause. 1. Physiological factors: under normal circumstances, the testicles on both sides of the scrotum are usually large and small, not completely symmetrical, if the difference in the size of the two testicles is not very obvious, it is usually a normal physiological phenomenon. 2. Pathological factors: (1) Orchitis: due to inflammation and infection of the testicles, edema and blood circulation restriction of the testicles, causing enlargement of the affected testicles and thus the two testicles are not the same size. (2) Testicular syringomyelia: due to the imbalance of secretion and absorption function of testicular syringomyelia, the syringomyelia accumulates too much fluid and a large amount of fluid is accumulated, thus causing the testicles to be swollen and appear as two testicles of different sizes. Two testicles of different sizes may also be caused by other factors, if two testicles of different sizes and accompanied by obvious discomfort, it is recommended that patients go to regular hospitals in a timely manner, please ask the doctor to clarify the cause of the disease, give targeted treatment, and strive for early recovery.