HBV-DNA quantification of 1.53E + 03, if liver function, ultrasound and other test results are normal, generally not serious; need to be combined with other test results to determine the overall. Generally speaking, HBV-DNA test is a direct standard for detecting whether the virus is in an active state of replication, and HBV-DNA quantification of 1.53E+03 is generally regarded as the virus replicating in a low amount, which needs to be strengthened by following up, and checking whether the liver function is normal at the same time. If there is no obvious liver function impairment, it is possible to follow up and observe, and to strengthen the re-examination. However, if there is obvious liver function damage, firstly, it is necessary to improve the liver ultrasound and other tests to make a comprehensive judgment. At the same time, it is necessary to detect whether there is a combination of other liver diseases, such as hepatitis C virus or alcoholic hepatitis, which can also lead to liver function damage. So whether it is serious or not needs to be analyzed in combination with other test results. Generally speaking, if there is no liver function damage, this test result is not serious. If there is a combination of liver injury, active treatment is needed.