High estrogen refers to high estrogen levels; estrogen receptor positive refers to a certain number of receptors in the target organ to which estrogen acts and binds. Estrogen is a sex hormone produced by the body whose primary role is to prompt and maintain the first and second sexual characteristics of women. The estrogen receptor is the receptor to which estrogen binds. It is often found in target organs, such as the mammary glands and endometrium in normal women, which have a high number of estrogen receptors. The receptor binds to estrogen and ultimately exerts a biological effect. Estrogen receptor testing is often used to diagnose estrogen-dependent tumors, such as in the treatment of endometrial and breast cancer. If a patient with breast or endometrial cancer has a positive estrogen receptor, it means that the treatment can be replaced with progesterone along with anti-tumor therapy, which can be relatively effective. It is recommended that women with both high estrogen and positive estrogen receptor should seek timely medical attention and standardize their treatment under the guidance of their doctors.